Drug interactions
Revefenacin + Umeclidinium
Severity: Moderate
Revefenacin and Umeclidinium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy. This increases the risk of anticholinergic effects such as dry mouth, urinary retention, constipation and narrow-angle glaucoma worsening, without clear added benefit.
What this interaction means in plain words
Revefenacin and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Umeclidinium belongs to Respiratory.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Avoid using two long-acting muscarinic antagonists together; choose one agent. If combined, monitor for urinary retention and ocular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium
- Tiotropium + Umeclidinium Major
- Aclidinium + Umeclidinium Moderate
- Atropine iv / + Umeclidinium Moderate
- Atropine + Umeclidinium Moderate
- Belladonna alkaloids + Umeclidinium Moderate
- Bethanechol + Umeclidinium Moderate
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Umeclidinium?
MediHelp rates the interaction as moderate. Revefenacin and Umeclidinium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are inhaled long-acting muscarinic antagonists, so combining them duplicates therapy. This increases the risk of anticholinergic effects such as dry mouth, urinary retention, constipation and narrow-angle glaucoma worsening, without clear added benefit.
How serious is the interaction between Revefenacin and Umeclidinium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting muscarinic antagonists together; choose one agent. If combined, monitor for urinary retention and ocular symptoms.
What other medicines interact with Umeclidinium?
MediHelp also lists interactions of Umeclidinium with, for example, Tiotropium, Aclidinium, Atropine iv /. The full list is on the Umeclidinium page.
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