Drug interactions
Ribociclib + Tasimelteon
Severity: Minor
Ribociclib and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise tasimelteon concentrations because tasimelteon is partly metabolized by CYP3A4. This could increase somnolence or headache, though the effect is expected to be modest.
What this interaction means in plain words
Ribociclib and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Tasimelteon belongs to Central Nervous System.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolism of tasimelteon, which is also cleared by CYP1A2.
What to do
No routine adjustment is needed; watch for daytime drowsiness and reduce use if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Ribociclib with Tasimelteon?
MediHelp rates the interaction as minor. Ribociclib and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib may raise tasimelteon concentrations because tasimelteon is partly metabolized by CYP3A4. This could increase somnolence or headache, though the effect is expected to be modest.
How serious is the interaction between Ribociclib and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for daytime drowsiness and reduce use if adverse effects emerge.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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