Drug interactions
Ribociclib + Ticlopidine
Severity: Moderate
Ribociclib and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor, but ticlopidine's activity does not depend mainly on CYP3A4. Both drugs can cause neutropenia, so hematologic toxicity may be additive.
What this interaction means in plain words
Ribociclib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Ticlopidine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 inhibition by ribociclib altering ticlopidine metabolism; additive myelosuppression.
What to do
Monitor complete blood counts closely, especially neutrophils, during combined use. Consider an alternative antiplatelet agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Ticlopidine?
MediHelp rates the interaction as moderate. Ribociclib and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor, but ticlopidine's activity does not depend mainly on CYP3A4. Both drugs can cause neutropenia, so hematologic toxicity may be additive.
How serious is the interaction between Ribociclib and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely, especially neutrophils, during combined use. Consider an alternative antiplatelet agent.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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