Drug interactions
Ribociclib + Ubrogepant
Severity: Moderate
Ribociclib and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ubrogepant is a CYP3A4 substrate and strong CYP3A4 inhibitors are contraindicated. Ribociclib inhibits CYP3A4 and can raise ubrogepant exposure, increasing adverse effects such as nausea and somnolence. The effect is likely less than with strong inhibitors, but still relevant.
What this interaction means in plain words
Ribociclib and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Ubrogepant belongs to Central Nervous System.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of ubrogepant.
What to do
Use the lower 50 mg ubrogepant dose, and do not repeat the second dose for 24 hours when used with a moderate CYP3A4 inhibitor. Consider an alternative acute migraine therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Ribociclib with Ubrogepant?
MediHelp rates the interaction as moderate. Ribociclib and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ubrogepant is a CYP3A4 substrate and strong CYP3A4 inhibitors are contraindicated. Ribociclib inhibits CYP3A4 and can raise ubrogepant exposure, increasing adverse effects such as nausea and somnolence. The effect is likely less than with strong inhibitors, but still relevant.
How serious is the interaction between Ribociclib and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower 50 mg ubrogepant dose, and do not repeat the second dose for 24 hours when used with a moderate CYP3A4 inhibitor. Consider an alternative acute migraine therapy.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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