Drug interactions
Ribociclib + Vilazodone
Severity: Moderate
Ribociclib and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and can raise vilazodone concentrations, which may increase serotonergic adverse effects. Both drugs have QT-related concerns (ribociclib clearly, vilazodone less so), which adds to the clinical caution.
What this interaction means in plain words
Ribociclib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Ribociclib inhibits CYP3A4, reducing vilazodone clearance.
What to do
Monitor for vilazodone toxicity and reduce the dose to 20 mg daily if adverse effects are intolerable. Check ECG and electrolytes per ribociclib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vilazodone?
MediHelp rates the interaction as moderate. Ribociclib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and can raise vilazodone concentrations, which may increase serotonergic adverse effects. Both drugs have QT-related concerns (ribociclib clearly, vilazodone less so), which adds to the clinical caution.
How serious is the interaction between Ribociclib and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vilazodone toxicity and reduce the dose to 20 mg daily if adverse effects are intolerable. Check ECG and electrolytes per ribociclib labeling.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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