Drug interactions
Riluzole + Ritlecitinib
Severity: Moderate
Riluzole and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib inhibits CYP1A2, the main enzyme metabolizing riluzole. Riluzole levels may rise, increasing the risk of adverse effects such as nausea, dizziness and hepatotoxicity.
What this interaction means in plain words
Riluzole and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riluzole belongs to Miscellaneous; Ritlecitinib belongs to Oncology.
Why it happens
CYP1A2 inhibition by ritlecitinib reduces riluzole clearance.
What to do
Monitor liver enzymes and tolerability of riluzole during co-treatment. Reduce the riluzole dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Riluzole with Ritlecitinib?
MediHelp rates the interaction as moderate. Riluzole and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib inhibits CYP1A2, the main enzyme metabolizing riluzole. Riluzole levels may rise, increasing the risk of adverse effects such as nausea, dizziness and hepatotoxicity.
How serious is the interaction between Riluzole and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability of riluzole during co-treatment. Reduce the riluzole dose if adverse effects occur.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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