Drug interactions
Riluzole + Talquetamab
Severity: Moderate
Riluzole and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Riluzole is metabolized by CYP1A2, so exposure may increase, mainly during step-up dosing and around cytokine release events.
What this interaction means in plain words
Riluzole and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Riluzole belongs to Miscellaneous; Talquetamab belongs to Oncology.
Why it happens
Cytokine release suppresses CYP1A2 activity, decreasing riluzole metabolism.
What to do
Monitor for riluzole adverse effects and liver tests during talquetamab step-up and for about two weeks after the first treatment dose. Reduce or hold riluzole if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Riluzole with Talquetamab?
MediHelp rates the interaction as moderate. Riluzole and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release syndrome, which can transiently suppress CYP enzymes. Riluzole is metabolized by CYP1A2, so exposure may increase, mainly during step-up dosing and around cytokine release events.
How serious is the interaction between Riluzole and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for riluzole adverse effects and liver tests during talquetamab step-up and for about two weeks after the first treatment dose. Reduce or hold riluzole if toxicity emerges.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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