Drug interactions
Risperidone + Stiripentol
Severity: Moderate
Risperidone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol may raise risperidone exposure and adds to sedation and somnolence. Adverse effects such as sedation, parkinsonism or hypotension may become more prominent.
What this interaction means in plain words
Risperidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-glycoprotein and CYP enzymes involved in risperidone disposition, plus additive CNS depression.
What to do
Monitor for sedation and extrapyramidal symptoms and reduce the risperidone dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Risperidone with Stiripentol?
MediHelp rates the interaction as moderate. Risperidone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol may raise risperidone exposure and adds to sedation and somnolence. Adverse effects such as sedation, parkinsonism or hypotension may become more prominent.
How serious is the interaction between Risperidone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and extrapyramidal symptoms and reduce the risperidone dose if adverse effects occur.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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