Drug interactions
Risperidone + Valbenazine
Severity: Moderate
Risperidone and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect QT interval, and valbenazine may cause QT prolongation at higher exposures. Combined use may add to arrhythmia risk, and both can cause somnolence and parkinsonism.
What this interaction means in plain words
Risperidone and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS effects.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes, and watch for somnolence and parkinsonism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Risperidone with Valbenazine?
MediHelp rates the interaction as moderate. Risperidone and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can affect QT interval, and valbenazine may cause QT prolongation at higher exposures. Combined use may add to arrhythmia risk, and both can cause somnolence and parkinsonism.
How serious is the interaction between Risperidone and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes, and watch for somnolence and parkinsonism.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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