Drug interactions
Ritonavir + Rolapitant
Severity: Minor
Ritonavir and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits CYP2D6, but ritonavir is cleared mainly by CYP3A4, with CYP2D6 contributing only minor metabolism. A meaningful rise in ritonavir exposure is therefore unlikely.
What this interaction means in plain words
Ritonavir and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ritonavir belongs to Anti Virals; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant CYP2D6 inhibition may slightly reduce the minor CYP2D6 metabolism of ritonavir.
What to do
No dose adjustment is needed. Monitor for ritonavir adverse effects such as gastrointestinal upset if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Rolapitant?
MediHelp rates the interaction as minor. Ritonavir and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rolapitant inhibits CYP2D6, but ritonavir is cleared mainly by CYP3A4, with CYP2D6 contributing only minor metabolism. A meaningful rise in ritonavir exposure is therefore unlikely.
How serious is the interaction between Ritonavir and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for ritonavir adverse effects such as gastrointestinal upset if symptoms occur.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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