Drug interactions
Rizatriptan + Tedizolid
Severity: Moderate
Rizatriptan and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan is a 5-HT1B/1D agonist and is metabolized mainly by MAO-A. A weak MAO inhibitor such as tedizolid could raise rizatriptan exposure and add serotonergic effects. Clinically significant effects appear uncommon.
What this interaction means in plain words
Rizatriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rizatriptan belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Weak MAO-A inhibition by tedizolid may reduce rizatriptan clearance, adding to serotonergic agonism.
What to do
Monitor for serotonin toxicity and excessive triptan effects. Choose a non-serotonergic antibiotic where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Rizatriptan with Tedizolid?
MediHelp rates the interaction as moderate. Rizatriptan and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rizatriptan is a 5-HT1B/1D agonist and is metabolized mainly by MAO-A. A weak MAO inhibitor such as tedizolid could raise rizatriptan exposure and add serotonergic effects. Clinically significant effects appear uncommon.
How serious is the interaction between Rizatriptan and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and excessive triptan effects. Choose a non-serotonergic antibiotic where practical.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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