Drug interactions
Rolapitant + Selexipag
Severity: Moderate
Rolapitant and Selexipag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits BCRP and selexipag is a BCRP substrate, so exposure to selexipag may increase. This could amplify prostacyclin-type effects such as headache, flushing, diarrhea and jaw pain.
What this interaction means in plain words
Rolapitant and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Selexipag belongs to Cardiovascular.
Why it happens
Inhibition of BCRP efflux by rolapitant may increase selexipag absorption and reduce its clearance.
What to do
Monitor for increased selexipag adverse effects while rolapitant is used. Reduce the selexipag dose only if tolerability problems develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rolapitant and Selexipag, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Rolapitant with Selexipag?
MediHelp rates the interaction as moderate. Rolapitant and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits BCRP and selexipag is a BCRP substrate, so exposure to selexipag may increase. This could amplify prostacyclin-type effects such as headache, flushing, diarrhea and jaw pain.
How serious is the interaction between Rolapitant and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased selexipag adverse effects while rolapitant is used. Reduce the selexipag dose only if tolerability problems develop.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
