Drug interactions
Rolapitant + Sertraline
Severity: Minor
Rolapitant and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is metabolized by several enzymes, with CYP2D6 contributing only a minor part. Rolapitant is unlikely to change sertraline exposure much, although a small increase in adverse effects is conceivable.
What this interaction means in plain words
Rolapitant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rolapitant belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Rolapitant inhibits CYP2D6, which is only a minor pathway for sertraline metabolism.
What to do
No dose adjustment is needed. Monitor for typical sertraline adverse effects such as nausea or agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Rolapitant with Sertraline?
MediHelp rates the interaction as minor. Rolapitant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is metabolized by several enzymes, with CYP2D6 contributing only a minor part. Rolapitant is unlikely to change sertraline exposure much, although a small increase in adverse effects is conceivable.
How serious is the interaction between Rolapitant and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for typical sertraline adverse effects such as nausea or agitation.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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