Drug interactions
Rolapitant + Tamsulosin
Severity: Moderate
Rolapitant and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits CYP2D6 for a prolonged period, which may increase tamsulosin exposure. This may cause more hypotension, dizziness, or syncope.
What this interaction means in plain words
Rolapitant and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Tamsulosin belongs to Genitourinary.
Why it happens
Rolapitant inhibits CYP2D6-mediated metabolism of tamsulosin.
What to do
Monitor for orthostatic hypotension and dizziness, particularly in the weeks after rolapitant. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Rolapitant with Tamsulosin?
MediHelp rates the interaction as moderate. Rolapitant and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits CYP2D6 for a prolonged period, which may increase tamsulosin exposure. This may cause more hypotension, dizziness, or syncope.
How serious is the interaction between Rolapitant and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, particularly in the weeks after rolapitant. Counsel patients to rise slowly.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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