Drug interactions
Rolapitant + Topotecan
Severity: Moderate
Rolapitant and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits BCRP, and topotecan is a BCRP substrate, so its exposure may rise. This may worsen myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Rolapitant and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Topotecan belongs to Oncology.
Why it happens
Rolapitant inhibits BCRP efflux, increasing topotecan absorption and reducing elimination.
What to do
Monitor complete blood counts and for gastrointestinal toxicity. Adjust the topotecan dose per hematologic tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Rolapitant with Topotecan?
MediHelp rates the interaction as moderate. Rolapitant and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rolapitant inhibits BCRP, and topotecan is a BCRP substrate, so its exposure may rise. This may worsen myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Rolapitant and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for gastrointestinal toxicity. Adjust the topotecan dose per hematologic tolerance.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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