Drug interactions
Ropivacaine + Rucaparib
Severity: Minor
Ropivacaine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2 and, to a lesser extent, CYP3A4, the enzymes that metabolize ropivacaine. Ropivacaine exposure may rise, which matters mainly with prolonged infusions or repeated doses where accumulation could increase systemic toxicity.
What this interaction means in plain words
Ropivacaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ropivacaine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2 and CYP3A4, reducing ropivacaine metabolism.
What to do
No adjustment is usually needed for single doses; during prolonged infusions, watch for signs of local anesthetic systemic toxicity and consider a lower dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ropivacaine with Rucaparib?
MediHelp rates the interaction as minor. Ropivacaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2 and, to a lesser extent, CYP3A4, the enzymes that metabolize ropivacaine. Ropivacaine exposure may rise, which matters mainly with prolonged infusions or repeated doses where accumulation could increase systemic toxicity.
How serious is the interaction between Ropivacaine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed for single doses; during prolonged infusions, watch for signs of local anesthetic systemic toxicity and consider a lower dose.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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