Drug interactions
Rosiglitazone + Teriflunomide
Severity: Moderate
Rosiglitazone and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone is cleared mainly by CYP2C8, which teriflunomide inhibits. Exposure may increase, with more fluid retention and hypoglycemia.
What this interaction means in plain words
Rosiglitazone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 by teriflunomide reduces rosiglitazone metabolism.
What to do
Monitor blood glucose and for edema or heart failure signs, and reduce the rosiglitazone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Teriflunomide?
MediHelp rates the interaction as moderate. Rosiglitazone and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rosiglitazone is cleared mainly by CYP2C8, which teriflunomide inhibits. Exposure may increase, with more fluid retention and hypoglycemia.
How serious is the interaction between Rosiglitazone and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for edema or heart failure signs, and reduce the rosiglitazone dose if needed.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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