Drug interactions
Rucaparib + Ruxolitinib
Severity: Moderate
Rucaparib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate CYP3A4 inhibitor and could modestly raise ruxolitinib exposure. Cytopenias, already common with both drugs, may be worsened.
What this interaction means in plain words
Rucaparib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by rucaparib reduces ruxolitinib clearance, with overlapping myelosuppression.
What to do
Monitor complete blood counts regularly and reduce ruxolitinib dose if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Ruxolitinib?
MediHelp rates the interaction as moderate. Rucaparib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak-to-moderate CYP3A4 inhibitor and could modestly raise ruxolitinib exposure. Cytopenias, already common with both drugs, may be worsened.
How serious is the interaction between Rucaparib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce ruxolitinib dose if cytopenias develop.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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