Drug interactions
Rucaparib + Tramadol
Severity: Minor
Rucaparib and Tramadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2, CYP2C9, CYP2C19 and CYP3A, and may modestly increase tramadol levels via CYP3A4. The clinical effect is likely small and has not been well studied.
What this interaction means in plain words
Rucaparib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
Weak to moderate inhibition of CYP3A4-mediated tramadol N-demethylation by rucaparib.
What to do
No routine adjustment is needed. Monitor for opioid adverse effects such as sedation and nausea and reduce the tramadol dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tramadol?
MediHelp rates the interaction as minor. Rucaparib and Tramadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2, CYP2C9, CYP2C19 and CYP3A, and may modestly increase tramadol levels via CYP3A4. The clinical effect is likely small and has not been well studied.
How serious is the interaction between Rucaparib and Tramadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for opioid adverse effects such as sedation and nausea and reduce the tramadol dose if they appear.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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