Drug interactions
Rucaparib + Trimipramine
Severity: Moderate
Rucaparib and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 and other enzymes, which may increase trimipramine exposure. Higher levels can lead to more anticholinergic, sedative, and cardiac adverse effects.
What this interaction means in plain words
Rucaparib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Trimipramine belongs to Central Nervous System.
Why it happens
Rucaparib inhibition of CYP2C19 (and CYP2D6) reduces trimipramine metabolism.
What to do
Monitor for tricyclic toxicity and consider reducing the trimipramine dose or checking plasma levels. Obtain an ECG if symptoms suggest toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Trimipramine?
MediHelp rates the interaction as moderate. Rucaparib and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C19 and other enzymes, which may increase trimipramine exposure. Higher levels can lead to more anticholinergic, sedative, and cardiac adverse effects.
How serious is the interaction between Rucaparib and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider reducing the trimipramine dose or checking plasma levels. Obtain an ECG if symptoms suggest toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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