Drug interactions
Rucaparib + Vortioxetine
Severity: Minor
Rucaparib and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and CYP2C19 among others, which may modestly increase vortioxetine concentrations. Vortioxetine is mainly cleared via CYP2D6, so the effect is likely small.
What this interaction means in plain words
Rucaparib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP-mediated vortioxetine metabolism by rucaparib.
What to do
No empirical dose change is needed. Monitor for nausea and other dose-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Vortioxetine?
MediHelp rates the interaction as minor. Rucaparib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 and CYP2C19 among others, which may modestly increase vortioxetine concentrations. Vortioxetine is mainly cleared via CYP2D6, so the effect is likely small.
How serious is the interaction between Rucaparib and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for nausea and other dose-related adverse effects.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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