Drug interactions
Rucaparib + Zonisamide
Severity: Minor
Rucaparib and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and might modestly raise zonisamide concentrations. The effect is likely small, but increased drowsiness, dizziness or other adverse effects of zonisamide could appear.
What this interaction means in plain words
Rucaparib and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Zonisamide belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces the metabolism of zonisamide.
What to do
Monitor for zonisamide adverse effects such as somnolence and dizziness after rucaparib is started. Reduce the zonisamide dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Zonisamide?
MediHelp rates the interaction as minor. Rucaparib and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and might modestly raise zonisamide concentrations. The effect is likely small, but increased drowsiness, dizziness or other adverse effects of zonisamide could appear.
How serious is the interaction between Rucaparib and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide adverse effects such as somnolence and dizziness after rucaparib is started. Reduce the zonisamide dose if toxicity develops.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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