Drug interactions
Ruxolitinib + Stiripentol
Severity: Moderate
Ruxolitinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibiting and inducing effects on CYP3A4, so ruxolitinib exposure may rise or fall unpredictably. Either loss of efficacy or increased cytopenias could occur.
What this interaction means in plain words
Ruxolitinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ruxolitinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters ruxolitinib metabolism.
What to do
Monitor blood counts and clinical response, and adjust ruxolitinib dose as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Stiripentol
Frequently asked questions
Can I take Ruxolitinib with Stiripentol?
MediHelp rates the interaction as moderate. Ruxolitinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibiting and inducing effects on CYP3A4, so ruxolitinib exposure may rise or fall unpredictably. Either loss of efficacy or increased cytopenias could occur.
How serious is the interaction between Ruxolitinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response, and adjust ruxolitinib dose as indicated.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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