Drug interactions
Ruxolitinib + Trazodone
Severity: Minor
Ruxolitinib and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is at most a weak CYP3A4 inhibitor, so a clinically important rise in ruxolitinib exposure is unlikely. Trazodone is mainly a CYP3A4 substrate rather than an inhibitor.
What this interaction means in plain words
Ruxolitinib and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ruxolitinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Theoretical weak inhibition of CYP3A4-mediated ruxolitinib metabolism.
What to do
No dose adjustment is needed; monitor blood counts as routinely done for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ruxolitinib with Trazodone?
MediHelp rates the interaction as minor. Ruxolitinib and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone is at most a weak CYP3A4 inhibitor, so a clinically important rise in ruxolitinib exposure is unlikely. Trazodone is mainly a CYP3A4 substrate rather than an inhibitor.
How serious is the interaction between Ruxolitinib and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood counts as routinely done for ruxolitinib.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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