Drug interactions
Saxagliptin + Tepotinib
Severity: Minor
Saxagliptin and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may modestly raise saxagliptin exposure. Saxagliptin has a wide therapeutic margin, so the effect is probably small.
What this interaction means in plain words
Saxagliptin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saxagliptin belongs to Endocrine; Tepotinib belongs to Oncology.
Why it happens
P-gp inhibition by tepotinib reduces efflux of saxagliptin.
What to do
No dose adjustment is routinely needed. Monitor for hypoglycemia and other adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Saxagliptin with Tepotinib?
MediHelp rates the interaction as minor. Saxagliptin and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may modestly raise saxagliptin exposure. Saxagliptin has a wide therapeutic margin, so the effect is probably small.
How serious is the interaction between Saxagliptin and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for hypoglycemia and other adverse effects.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
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