Drug interactions
Secobarbital + Silodosin
Severity: Moderate
Secobarbital and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may reduce silodosin exposure, potentially weakening its effect. The clinical effect has not been well studied, and additive sedation or dizziness may also occur.
What this interaction means in plain words
Secobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Silodosin belongs to Genitourinary.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases silodosin metabolism.
What to do
Monitor for reduced symptom relief and for orthostatic dizziness; consider an alternative if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Silodosin?
MediHelp rates the interaction as moderate. Secobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may reduce silodosin exposure, potentially weakening its effect. The clinical effect has not been well studied, and additive sedation or dizziness may also occur.
How serious is the interaction between Secobarbital and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom relief and for orthostatic dizziness; consider an alternative if efficacy is lost.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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