Drug interactions
Secukinumab + Sirolimus
Severity: Minor
Secukinumab and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab reduces IL-17-driven inflammation, which might restore cytokine-suppressed CYP activity. Any effect on sirolimus levels is likely small and not clearly established.
What this interaction means in plain words
Secukinumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Secukinumab belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Theoretical normalisation of cytokine-suppressed CYP3A4 expression.
What to do
Consider checking sirolimus trough levels after starting or stopping secukinumab and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Frequently asked questions
Can I take Secukinumab with Sirolimus?
MediHelp rates the interaction as minor. Secukinumab and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab reduces IL-17-driven inflammation, which might restore cytokine-suppressed CYP activity. Any effect on sirolimus levels is likely small and not clearly established.
How serious is the interaction between Secukinumab and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking sirolimus trough levels after starting or stopping secukinumab and adjust the dose if needed.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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