Drug interactions
Secukinumab + Trastuzumab deruxtecan
Severity: Moderate
Secukinumab and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab blocks IL-17A and modestly raises infection susceptibility, while trastuzumab deruxtecan commonly causes neutropenia. Used together, the risk of infections may be higher than with either drug alone, though no specific interaction has been well characterized.
What this interaction means in plain words
Secukinumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secukinumab belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive effects: immunomodulation by IL-17A inhibition plus myelosuppression from the antibody-drug conjugate payload.
What to do
Monitor neutrophil counts and watch for signs of infection during combined therapy. Treat infections promptly and follow trastuzumab deruxtecan dose-hold guidance for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Secukinumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Secukinumab and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secukinumab blocks IL-17A and modestly raises infection susceptibility, while trastuzumab deruxtecan commonly causes neutropenia. Used together, the risk of infections may be higher than with either drug alone, though no specific interaction has been well characterized.
How serious is the interaction between Secukinumab and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and watch for signs of infection during combined therapy. Treat infections promptly and follow trastuzumab deruxtecan dose-hold guidance for neutropenia.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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