Drug interactions
Sevoflurane + Sotalol
Severity: Moderate
Sevoflurane and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and may add to the effect of sotalol, increasing perioperative torsades risk. Both can also lower blood pressure and heart rate.
What this interaction means in plain words
Sevoflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation and cardiovascular depression.
What to do
Tell the anesthesia team about sotalol and check preoperative ECG and electrolytes. Monitor ECG continuously and avoid other QT-prolonging drugs such as ondansetron if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Sotalol?
MediHelp rates the interaction as moderate. Sevoflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval and may add to the effect of sotalol, increasing perioperative torsades risk. Both can also lower blood pressure and heart rate.
How serious is the interaction between Sevoflurane and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about sotalol and check preoperative ECG and electrolytes. Monitor ECG continuously and avoid other QT-prolonging drugs such as ondansetron if possible.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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