Drug interactions
Sevoflurane + Tramadol
Severity: Moderate
Sevoflurane and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce the anesthetic requirement of sevoflurane and add to respiratory and cardiovascular depression. This is a routine perioperative combination but needs careful titration.
What this interaction means in plain words
Sevoflurane and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS, respiratory and hemodynamic depression.
What to do
Titrate the volatile agent to effect with continuous monitoring of ventilation and blood pressure, and anticipate postoperative respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Tramadol?
MediHelp rates the interaction as moderate. Sevoflurane and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids reduce the anesthetic requirement of sevoflurane and add to respiratory and cardiovascular depression. This is a routine perioperative combination but needs careful titration.
How serious is the interaction between Sevoflurane and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the volatile agent to effect with continuous monitoring of ventilation and blood pressure, and anticipate postoperative respiratory depression.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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