Drug interactions
Sevoflurane + Trazodone
Severity: Moderate
Sevoflurane and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and trazodone has similar potential, so perioperative torsades risk may rise. Anesthetic-related hypotension may also be amplified by trazodone's alpha-blocking effect.
What this interaction means in plain words
Sevoflurane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation and additive hypotensive effects.
What to do
Inform the anesthesia team and review the baseline QTc and electrolytes before surgery. Monitor ECG during and after anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Trazodone?
MediHelp rates the interaction as moderate. Sevoflurane and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and trazodone has similar potential, so perioperative torsades risk may rise. Anesthetic-related hypotension may also be amplified by trazodone's alpha-blocking effect.
How serious is the interaction between Sevoflurane and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and review the baseline QTc and electrolytes before surgery. Monitor ECG during and after anesthesia.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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