Drug interactions
Sevoflurane + Triclabendazole
Severity: Moderate
Sevoflurane and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval and sevoflurane has similar effects on repolarization. Combined use may increase the likelihood of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Sevoflurane and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT interval prolongation.
What to do
If anesthesia is needed during treatment, check ECG and electrolytes beforehand and monitor the ECG throughout. Postpone elective procedures until triclabendazole treatment is complete where practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Triclabendazole
Frequently asked questions
Can I take Sevoflurane with Triclabendazole?
MediHelp rates the interaction as moderate. Sevoflurane and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval and sevoflurane has similar effects on repolarization. Combined use may increase the likelihood of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Sevoflurane and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If anesthesia is needed during treatment, check ECG and electrolytes beforehand and monitor the ECG throughout. Postpone elective procedures until triclabendazole treatment is complete where practical.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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