Drug interactions
Sevoflurane + Trimipramine
Severity: Moderate
Sevoflurane and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and deepens sedation, and tricyclics sensitise the heart to arrhythmia and hypotension. Perioperative arrhythmia and haemodynamic instability may occur.
What this interaction means in plain words
Sevoflurane and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, CNS depression and cardiovascular effects.
What to do
Alert the anaesthesia team and use continuous ECG monitoring. Correct electrolytes and avoid other QT-prolonging drugs perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Trimipramine?
MediHelp rates the interaction as moderate. Sevoflurane and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval and deepens sedation, and tricyclics sensitise the heart to arrhythmia and hypotension. Perioperative arrhythmia and haemodynamic instability may occur.
How serious is the interaction between Sevoflurane and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Alert the anaesthesia team and use continuous ECG monitoring. Correct electrolytes and avoid other QT-prolonging drugs perioperatively.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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