Drug interactions
Sevoflurane + Valbenazine
Severity: Moderate
Sevoflurane and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both valbenazine and sevoflurane can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias such as torsades de pointes. The risk is greater with electrolyte disturbance, bradycardia or other QT-prolonging drugs.
What this interaction means in plain words
Sevoflurane and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before surgery. Monitor the ECG continuously during anesthesia and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Sevoflurane with Valbenazine?
MediHelp rates the interaction as moderate. Sevoflurane and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both valbenazine and sevoflurane can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias such as torsades de pointes. The risk is greater with electrolyte disturbance, bradycardia or other QT-prolonging drugs.
How serious is the interaction between Sevoflurane and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia before surgery. Monitor the ECG continuously during anesthesia and avoid other QT-prolonging drugs.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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