Drug interactions
Silodosin + Tamsulosin
Severity: Major
Silodosin and Tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are alpha-1 blockers used for benign prostatic hyperplasia, so combining them offers no added benefit and increases hypotension, dizziness and syncope risk.
What this interaction means in plain words
Silodosin and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Silodosin belongs to Genitourinary; Tamsulosin belongs to Genitourinary.
Why it happens
Duplicate alpha-1 adrenergic receptor antagonism.
What to do
Do not use together; choose one alpha-blocker. When switching, stop the first agent before starting the second.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Silodosin with Tamsulosin?
MediHelp rates the interaction as major. Silodosin and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are alpha-1 blockers used for benign prostatic hyperplasia, so combining them offers no added benefit and increases hypotension, dizziness and syncope risk.
How serious is the interaction between Silodosin and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one alpha-blocker. When switching, stop the first agent before starting the second.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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