Drug interactions
Silodosin + Vardenafil
Severity: Major
Silodosin and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil and silodosin both can lower blood pressure, and combined use may cause orthostatic hypotension, dizziness or syncope. Labeling for vardenafil advises against use with alpha-blockers other than at the lowest dose in stable patients.
What this interaction means in plain words
Silodosin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Silodosin belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1A adrenergic blockade and PDE5 inhibition.
What to do
Avoid the combination where possible; if used, begin vardenafil at the lowest dose once the patient is stable on silodosin. Monitor standing blood pressure and warn about dizziness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Silodosin with Vardenafil?
MediHelp rates the interaction as major. Silodosin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vardenafil and silodosin both can lower blood pressure, and combined use may cause orthostatic hypotension, dizziness or syncope. Labeling for vardenafil advises against use with alpha-blockers other than at the lowest dose in stable patients.
How serious is the interaction between Silodosin and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, begin vardenafil at the lowest dose once the patient is stable on silodosin. Monitor standing blood pressure and warn about dizziness.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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