Drug interactions
Siltuximab + Temsirolimus
Severity: Moderate
Siltuximab and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-6 with siltuximab can reverse cytokine-mediated suppression of CYP enzymes. This may increase CYP3A4 activity and lower concentrations of temsirolimus and sirolimus, potentially reducing efficacy.
What this interaction means in plain words
Siltuximab and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siltuximab belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Siltuximab neutralizes IL-6, normalizing suppressed CYP3A4 expression and increasing temsirolimus metabolism.
What to do
Monitor tumor response and temsirolimus tolerability when siltuximab is started or stopped. Adjust the dose according to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Siltuximab with Temsirolimus?
MediHelp rates the interaction as moderate. Siltuximab and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-6 with siltuximab can reverse cytokine-mediated suppression of CYP enzymes. This may increase CYP3A4 activity and lower concentrations of temsirolimus and sirolimus, potentially reducing efficacy.
How serious is the interaction between Siltuximab and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and temsirolimus tolerability when siltuximab is started or stopped. Adjust the dose according to clinical effect.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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