Drug interactions
Sodium zirconium cyclosilicate + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Sodium zirconium cyclosilicate and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH, and velpatasvir solubility falls as pH rises. Lower velpatasvir absorption may reduce antiviral efficacy and the chance of sustained virologic response.
What this interaction means in plain words
Sodium zirconium cyclosilicate and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sodium zirconium cyclosilicate belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of velpatasvir.
What to do
Give sodium zirconium cyclosilicate at least 2 hours before or after the antiviral combination, and confirm the treatment response with HCV RNA testing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sodium zirconium cyclosilicate and Sofosbuvir-velpatasvir-voxilaprevir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Sodium zirconium cyclosilicate with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Sodium zirconium cyclosilicate and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate can raise gastric pH, and velpatasvir solubility falls as pH rises. Lower velpatasvir absorption may reduce antiviral efficacy and the chance of sustained virologic response.
How serious is the interaction between Sodium zirconium cyclosilicate and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give sodium zirconium cyclosilicate at least 2 hours before or after the antiviral combination, and confirm the treatment response with HCV RNA testing.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
