Drug interactions
Sofosbuvir + Vadadustat
Severity: Minor
Sofosbuvir and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase exposure to BCRP substrates such as sofosbuvir. The clinical importance is uncertain, as sofosbuvir has a wide safety margin, but increased adverse effects are conceivable.
What this interaction means in plain words
Sofosbuvir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits breast cancer resistance protein (BCRP), potentially reducing efflux of sofosbuvir and raising its exposure.
What to do
No dose adjustment is established; monitor for sofosbuvir-related adverse effects such as headache, fatigue and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Sofosbuvir with Vadadustat?
MediHelp rates the interaction as minor. Sofosbuvir and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits BCRP and may increase exposure to BCRP substrates such as sofosbuvir. The clinical importance is uncertain, as sofosbuvir has a wide safety margin, but increased adverse effects are conceivable.
How serious is the interaction between Sofosbuvir and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is established; monitor for sofosbuvir-related adverse effects such as headache, fatigue and nausea.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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