Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Talazoparib
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and may raise talazoparib exposure, increasing myelosuppression such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Talazoparib belongs to Oncology.
Why it happens
Inhibition of intestinal BCRP by velpatasvir increases talazoparib absorption and systemic exposure.
What to do
Monitor blood counts closely; reduce talazoparib dose per labeling for BCRP inhibitors if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Talazoparib?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP and may raise talazoparib exposure, increasing myelosuppression such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely; reduce talazoparib dose per labeling for BCRP inhibitors if toxicity develops.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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