Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tepotinib
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to sofosbuvir, velpatasvir and voxilaprevir. These agents have a reasonably wide safety margin, so the increase is usually modest in clinical terms.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-glycoprotein, reducing efflux of the HCV drugs and increasing absorption.
What to do
Monitor for HCV drug adverse effects such as headache, fatigue and gastrointestinal upset. No empirical dose change is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tepotinib?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase exposure to sofosbuvir, velpatasvir and voxilaprevir. These agents have a reasonably wide safety margin, so the increase is usually modest in clinical terms.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for HCV drug adverse effects such as headache, fatigue and gastrointestinal upset. No empirical dose change is established.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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