Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tucatinib
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and P-gp inhibitor that may raise velpatasvir, voxilaprevir and sofosbuvir concentrations. The HCV drugs are generally well tolerated, so the increase is usually manageable.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4 and P-glycoprotein, decreasing metabolism and efflux of the HCV agents.
What to do
Monitor for adverse effects such as headache, fatigue and nausea. Watch for hepatotoxicity, as tucatinib also raises liver enzymes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tucatinib?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and P-gp inhibitor that may raise velpatasvir, voxilaprevir and sofosbuvir concentrations. The HCV drugs are generally well tolerated, so the increase is usually manageable.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as headache, fatigue and nausea. Watch for hepatotoxicity, as tucatinib also raises liver enzymes.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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