Drug interactions
Solifenacin + Tucatinib
Severity: Moderate
Solifenacin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4, the main enzyme clearing solifenacin, so solifenacin exposure can rise. This may increase anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and QT prolongation risk.
What this interaction means in plain words
Solifenacin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Solifenacin belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of CYP3A4-mediated solifenacin metabolism increases solifenacin plasma concentrations.
What to do
Monitor for anticholinergic adverse effects and limit solifenacin to 5 mg daily if tucatinib is co-prescribed; consider an alternative agent in patients with QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Solifenacin with Tucatinib?
MediHelp rates the interaction as moderate. Solifenacin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4, the main enzyme clearing solifenacin, so solifenacin exposure can rise. This may increase anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision and QT prolongation risk.
How serious is the interaction between Solifenacin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and limit solifenacin to 5 mg daily if tucatinib is co-prescribed; consider an alternative agent in patients with QT risk.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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