Drug interactions
Solriamfetol + Tranylcypromine
Severity: Contraindicated
Solriamfetol and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises synaptic dopamine and norepinephrine, and MAO inhibitors prevent their breakdown. The combination can cause dangerous hypertension and tachycardia, and labeling contraindicates use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Solriamfetol and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Solriamfetol belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Dopamine and norepinephrine reuptake inhibition by solriamfetol combined with irreversible MAO inhibition gives additive adrenergic effects.
What to do
Do not co-administer. Wait at least 14 days after stopping tranylcypromine before starting solriamfetol.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Solriamfetol with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Solriamfetol and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Solriamfetol raises synaptic dopamine and norepinephrine, and MAO inhibitors prevent their breakdown. The combination can cause dangerous hypertension and tachycardia, and labeling contraindicates use during or within 14 days of MAOI therapy.
How serious is the interaction between Solriamfetol and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Wait at least 14 days after stopping tranylcypromine before starting solriamfetol.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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