Drug interactions
Sotalol + Tiotropium-olodaterol
Severity: Major
Sotalol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker that antagonizes olodaterol and can precipitate bronchospasm in patients with obstructive airway disease. Sotalol also prolongs the QT interval, and olodaterol-related hypokalemia may increase the risk of torsades de pointes.
What this interaction means in plain words
Sotalol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sotalol belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Non-selective beta2 blockade opposing olodaterol, plus additive QT prolongation and hypokalemia.
What to do
Avoid in patients with COPD or asthma where possible and choose a cardioselective alternative. If sotalol is essential, monitor respiratory function, ECG and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Sotalol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Sotalol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker that antagonizes olodaterol and can precipitate bronchospasm in patients with obstructive airway disease. Sotalol also prolongs the QT interval, and olodaterol-related hypokalemia may increase the risk of torsades de pointes.
How serious is the interaction between Sotalol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with COPD or asthma where possible and choose a cardioselective alternative. If sotalol is essential, monitor respiratory function, ECG and potassium.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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