Drug interactions
Stiripentol + Temsirolimus
Severity: Moderate
Stiripentol and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has mixed CYP3A4 inhibitory and inducing effects and inhibits P-gp, so temsirolimus exposure may change unpredictably. Either reduced efficacy or increased toxicity is possible.
What this interaction means in plain words
Stiripentol and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Stiripentol modulates CYP3A4 (inhibition and induction) and inhibits P-gp, altering temsirolimus and sirolimus disposition.
What to do
Monitor for both loss of efficacy and temsirolimus toxicity; adjust the temsirolimus dose according to clinical response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Temsirolimus?
MediHelp rates the interaction as moderate. Stiripentol and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has mixed CYP3A4 inhibitory and inducing effects and inhibits P-gp, so temsirolimus exposure may change unpredictably. Either reduced efficacy or increased toxicity is possible.
How serious is the interaction between Stiripentol and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both loss of efficacy and temsirolimus toxicity; adjust the temsirolimus dose according to clinical response and tolerability.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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