Drug interactions
Stiripentol + Tramadol
Severity: Moderate
Stiripentol and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2D6, CYP1A2 and CYP3A4 and can also induce some enzymes, so tramadol exposure and its metabolite formation may be unpredictably altered. It is also sedating and adds to tramadol's CNS depression, and tramadol can lower seizure threshold in patients with epilepsy.
What this interaction means in plain words
Stiripentol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Mixed CYP inhibition and induction by stiripentol plus additive CNS depression.
What to do
Monitor sedation, analgesic response and seizure frequency, and adjust tramadol dose accordingly. Consider an alternative analgesic in patients with unstable epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Tramadol?
MediHelp rates the interaction as moderate. Stiripentol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2D6, CYP1A2 and CYP3A4 and can also induce some enzymes, so tramadol exposure and its metabolite formation may be unpredictably altered. It is also sedating and adds to tramadol's CNS depression, and tramadol can lower seizure threshold in patients with epilepsy.
How serious is the interaction between Stiripentol and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, analgesic response and seizure frequency, and adjust tramadol dose accordingly. Consider an alternative analgesic in patients with unstable epilepsy.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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