Drug interactions
Stiripentol + Trimipramine
Severity: Moderate
Stiripentol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C19, CYP2D6 and CYP3A4, which metabolize trimipramine. Trimipramine levels may rise and cause anticholinergic, sedative and cardiac effects.
What this interaction means in plain words
Stiripentol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19, CYP2D6 and CYP3A4 metabolism of trimipramine, with possible CYP3A4 induction.
What to do
Consider a lower starting dose of trimipramine and monitor for toxicity, using plasma levels if available. Adjust the dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Trimipramine?
MediHelp rates the interaction as moderate. Stiripentol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP2C19, CYP2D6 and CYP3A4, which metabolize trimipramine. Trimipramine levels may rise and cause anticholinergic, sedative and cardiac effects.
How serious is the interaction between Stiripentol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower starting dose of trimipramine and monitor for toxicity, using plasma levels if available. Adjust the dose according to response.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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