Drug interactions
Stiripentol + Vortioxetine
Severity: Moderate
Stiripentol and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19, CYP3A4 and CYP2D6 in vitro and also induces some enzymes, so vortioxetine exposure may change unpredictably, likely increasing. The clinical effect has not been well characterized.
What this interaction means in plain words
Stiripentol and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Mixed CYP inhibition (including CYP2D6 and 2C19) and induction by stiripentol altering vortioxetine clearance.
What to do
Monitor for adverse effects and loss of efficacy and adjust the vortioxetine dose to response. Use the lowest effective dose initially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Vortioxetine?
MediHelp rates the interaction as moderate. Stiripentol and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19, CYP3A4 and CYP2D6 in vitro and also induces some enzymes, so vortioxetine exposure may change unpredictably, likely increasing. The clinical effect has not been well characterized.
How serious is the interaction between Stiripentol and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and loss of efficacy and adjust the vortioxetine dose to response. Use the lowest effective dose initially.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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