Drug interactions
Stiripentol + Zonisamide
Severity: Moderate
Stiripentol and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 and other enzymes and may change zonisamide exposure unpredictably. Both drugs are sedating, so somnolence, dizziness and impaired alertness can be additive.
What this interaction means in plain words
Stiripentol and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Stiripentol belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity (inhibition and induction) and both drugs have additive CNS depressant effects.
What to do
Monitor for sedation, ataxia and loss of seizure control, and adjust the zonisamide dose according to response and tolerability. Counsel patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Stiripentol with Zonisamide?
MediHelp rates the interaction as moderate. Stiripentol and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 and other enzymes and may change zonisamide exposure unpredictably. Both drugs are sedating, so somnolence, dizziness and impaired alertness can be additive.
How serious is the interaction between Stiripentol and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and loss of seizure control, and adjust the zonisamide dose according to response and tolerability. Counsel patients about driving and alcohol.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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